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Was (wer) ist myeloma protein - definition
Smouldering myeloma
MULTIPLE MYELOMA THAT IS A SLOW GROWING TYPE OF MYELOMA IN WHICH ABNORMAL PLASMA CELLS RESULTS IN TOO MUCH OF A SINGLE TYPE OF MONOCLONAL ANTIBODY
Smoldering myeloma; Smoldering multiple myeloma
Smouldering myeloma is a disease classified as intermediate in a spectrum of step-wise progressive diseases termed plasma cell dyscrasias. In this spectrum of diseases, a clone of plasma cells secreting monoclonal paraprotein (also termed myeloma protein or M protein) causes the relatively benign disease of monoclonal gammopathy of undetermined significance.
myeloma
![protein electropherogram]] showing a paraprotein (peak in the gamma zone) in a person with multiple myeloma](https://commons.wikimedia.org/wiki/Special:FilePath/Monoclonal gammopathy Multiple Myeloma.png?width=200 "protein electropherogram]] showing a paraprotein (peak in the gamma zone) in a person with multiple myeloma")
![Plasmablast, [[Wright stain]], in a case of multiple myeloma of plasmablastic type.](https://commons.wikimedia.org/wiki/Special:FilePath/Plasmablast, Wright stain.png?width=200 "Plasmablast, [[Wright stain]], in a case of multiple myeloma of plasmablastic type.")
![Bone marrow aspirate showing the histologic correlate of multiple myeloma under the microscope, [[H&E stain]]](https://commons.wikimedia.org/wiki/Special:FilePath/Multiple myeloma (2) HE stain.jpg?width=200 "Bone marrow aspirate showing the histologic correlate of multiple myeloma under the microscope, [[H&E stain]]")
![[[Micrograph]] showing myeloma [[cast nephropathy]] in a [[kidney biopsy]]: Hyaline casts are PAS positive (dark pink/red – right of image). Myelomatous casts are PAS negative (pale pink – left of image), [[PAS stain]].](https://commons.wikimedia.org/wiki/Special:FilePath/Cast nephropathy - 2 cropped - very high mag.jpg?width=200 "[[Micrograph]] showing myeloma [[cast nephropathy]] in a [[kidney biopsy]]: Hyaline casts are PAS positive (dark pink/red – right of image). Myelomatous casts are PAS negative (pale pink – left of image), [[PAS stain]].")
![[[Micrograph]] of a [[plasmacytoma]], [[H&E stain]]](https://commons.wikimedia.org/wiki/Special:FilePath/Plasmacytoma_ultramini1.jpg?width=200 "[[Micrograph]] of a [[plasmacytoma]], [[H&E stain]]")
![petrous]] temporal bones involving the mastoid segment of the [[facial nerve]] canal. Red arrows: lesion; green arrow: normal contralateral facial nerve canal. The lesions are consistent with a myeloma deposit.](https://commons.wikimedia.org/wiki/Special:FilePath/Multiple myeloma skull CT arrows.PNG?width=200 "petrous]] temporal bones involving the mastoid segment of the [[facial nerve]] canal. Red arrows: lesion; green arrow: normal contralateral facial nerve canal. The lesions are consistent with a myeloma deposit.")
![CT scan of the lower vertebral column in a man with multiple myeloma, showing multiple osteoblastic lesions: These are more [[radiodense]] (brighter in this image) than the surrounding [[cancellous bone]], in contrast to osteolytic lesions, which are less radiodense.](https://commons.wikimedia.org/wiki/Special:FilePath/CT of osteoblastic lesions of multiple myeloma.jpg?width=200 "CT scan of the lower vertebral column in a man with multiple myeloma, showing multiple osteoblastic lesions: These are more [[radiodense]] (brighter in this image) than the surrounding [[cancellous bone]], in contrast to osteolytic lesions, which are less radiodense.")
![[[Femur]] with multiple myeloma lesions](https://commons.wikimedia.org/wiki/Special:FilePath/Left femur with myeloma.jpg?width=200 "[[Femur]] with multiple myeloma lesions")
![[[Humerus]] with multiple myeloma lesions](https://commons.wikimedia.org/wiki/Special:FilePath/Left humerus with myeloma.jpg?width=200 "[[Humerus]] with multiple myeloma lesions")
CANCER OF PLASMA CELLS
Myeloma; Multiple Myeloma; Kahler's disease; Multiple myloma; Myeloma proteins; Lesions in the brain matter; Mulitple myeloma; Myloma; Bone-marrow cancer; Kahler's diseae; Plasma cell myeloma; Myelomatosis; Kahler disease; Myeloma, multiple; Myelomas; Myeloma solitary; Cutaneous infiltration by multiple myeloma; Myeloma nephrosis; Myeloma kidney; Kahler’s disease; Myelomatous meningitis; RRMM
[?m???'l??m?]
¦ noun (plural myelomas or myelomata -m?t?) Medicine a malignant tumour of the bone marrow.
Origin
C19: mod. L., from Gk muelos 'marrow' + -oma.
Protein–protein interaction
![[[Text mining]] protocol.](https://commons.wikimedia.org/wiki/Special:FilePath/Text mining protocol.png?width=200 "[[Text mining]] protocol.")
PHYSICAL INTERACTIONS AND CONSTRUCTIONS BETWEEN MULTIPLE PROTEINS
List of protein interactions; Protein-protein interactions; Protein protein interaction; Protein interaction; Protein-protein interaction assays; Protein-protein interaction; Protein–protein interactions; Protein-protein interface; Protein protein interfaces
Protein–protein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by interactions that include electrostatic forces, hydrogen bonding and the hydrophobic effect. Many are physical contacts with molecular associations between chains that occur in a cell or in a living organism in a specific biomolecular context.
Wikipedia
Myeloma protein
thumb|Serum [[protein electrophoresis showing a paraprotein (spike/peak in the gamma zone) in a patient with multiple myeloma.]]
